ftsA [2018-10-21 17:57:21]

cell division protein, membrane anchor for [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|FtsZ]

locus: BSU15280

pI: 5.09

mw: 47.94 kDa

protein length: 440 aa

gene length: 1320 bp

function: formation of Z-ring

product: [SW|cell division] protein

essential: yes

synonyms: spoIIN

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 1,596,474 → 1,597,796

Phenotypes of a mutant

• essential [Pubmed|28189581]
• cells become elongated [Pubmed|24218584]
• the ''[gene|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA]'' mutation is synthetically lethal with a ''[gene|DB09F1C36257F511A84A083967A25A9D46744D14|sepF]'' mutation [Pubmed|24218584]

The protein

Catalyzed reaction/ biological activity

• required for septum recruitment of [protein|DF77B46666595E86081C5345C91E08F86DF9FAEE|SftA] [pubmed|29439991]

Protein family

• ftsA/mreB family (according to Swiss-Prot)

Structure

• [PDB|3WQT] (from Staphylococcus aureus, 31% identity)

[SW|Localization]

• septal at the cell membrane (35% of the molecules) [Pubmed|29439991,20566861]
• cytoplasma (65% of the molecules) [pubmed|29439991]
• septal localization depends on the proton motive force [Pubmed|20566861]

Expression and Regulation

Operons

• genes: [gene|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA]-[gene|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ]
  description: [Pubmed|1569582]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1569582], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH]: sigma factor, [Pubmed|1569582], in [regulon|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH regulon]

  regulatory mechanism

  • [protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR]: activation, in [regulon|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|WalR regulon]

  regulation

  • activated by [protein|search|WalR] [Pubmed|10878122]

  additional information

  • half-life of the ''[SW|ftsZ]'' mRNA: 2.2 min [Pubmed|26110430]

Biological materials

Mutant

• 1A787 ( ''ftsA''::''cat''), [Pubmed|8071208], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A787&Search=1A787 BGSC]

References

Reviews

• 19680248,28254403

Original Publications

• 29439991,16796675,12081956,16159787,11298280,18776011,9287012,1569582,10878122,7592498,20566861,23036588,23701187,24218584,24224907,24316672,28189581